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Description

Category: Isotope Labelled Compounds, Peptides, Pharmaceuticals, Intermediates and Fine Chemicals /// Application Notes: Labelled Arginine Vasopressin. An endogenous antidiuretic hormone in most mammalian species. It is released into the blood from nerve terminals in the posterior pituitary and median eminence. It is a neurotransmitter in the central nervous system and also implicated in a variety of physiological processes such as regulating water balance by antidiuretic action. It is a peptidic V1a receptor agonist that produces vasoconstriction via V1aR-mediated vascular smooth muscle cell contraction and is being used to increase blood pressure in septic shock, a form of vasodilatory hypotension. /// References: Perucca, J. et al.: J. AM. Soc. Nephrol., 19, 1721 (2008)| Toba, K. et al.: Prog. Brain Res., 119, 337 (1998)| Berrada, K. et al.: J. Biol. Chem., 275, 27229 (2000)|