Item no.
TRC-A729803-10MG
CAS Number
[1133387-60-6]
Unit
10 mg
Molecular formula
C23H17D4F7N4O3
Molecular weight
538,45
Shipment details
No Dangerous Good
Back to your search result
Description
Category: Chiral Reagents, Heterocycles, Isotope Labelled Compounds, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: White Solid /// Application Notes: Aprepitant-d4 is a labeled analogue of Aprepitant (A729800), A novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Aprepitant-d4 is a potential treatment for chemotherapy induced nausea and vomiting. /// References: Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998)| Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001)| Van Belle, S., et al.: Cancer, 94, 3032 (2002)| Majumdar, A.K., et al.: J. Clin. Pharmacol., 46, 291 (2006)
Structure formula
Contents
Miscellaneous
Certificate of Analysis (specimen)
Reference Material CoA specimen: for the current lot, please contact your customer service representative at info@labmix24.com
Product data sheet
View all available product details e.g. description, analytes/parameters, CAS Number, concentrations/values, sales unit/product format, method, source, transport information
Quality analytical standards and reference materials for food and environmental analysis, research
Founded in 1982, Toronto Research Chemicals is specialized in the development and production of reference materials used in research as well as food safety testing and environmental analysis. The range of more than 350,000 products includes reference standards for pesticides and metabolites, impurities, natural compounds and complex organic small molecules not otherwise commercially available.