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Description

Application Notes: (2R,3R,1'S)-Aprepitant is an impurity of Aprepitant (A729800), a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic. /// References: Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998)| Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001)| Van Belle, S., et al.: Cancer, 94, 3032 (2002)| Majumdar, A.K., et al.: J. Clin. Pharmacol., 46, 291 (2006)| Ashok, S., et al.: J. Liq. Chromatogr. R. T., 35, 677 (2012)| Gangula, S., et al.: Synthetic Commun., 40, 2254 (2010)

Structure formula

Analyte

CAS Number

Concentration

Unit

Additional information

Method

(1S,2R,3R)-Aprepitant

[1242175-34-3]

Miscellaneous

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Quality analytical standards and reference materials for food and environmental analysis, research

Founded in 1982, Toronto Research Chemicals is specialized in the development and production of reference materials used in research as well as food safety testing and environmental analysis. The range of more than 350,000 products includes reference standards for pesticides and metabolites, impurities, natural compounds and complex organic small molecules not otherwise commercially available.