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Application Notes: 4-[4-[(Butylamino)carbonyl]-2-[[(2,4-dichlorophenyl)sulfonyl]amino]phenoxy]-3-methoxy-benzeneacetic Acid is a dual prostanoid D receptor (DP) and chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonist. DP and CRTH2 are involved in mediating allergic reactions (asthma, allergic rhinitis, and atopic dermatitis). Compounds that inhibit these receptors may hold potential for treating allergic diseases. /// References: Liu, J., et al.: Bioorg. Med. Chem. Lett. 19, 6419 (2009)| Liu, J., et al.: ACS Med Chem Lett. 2, 326 (2011)

Structure formula

Contents

Analyte

CAS Number

Concentration

Unit

Additional information

Method

4-[4-[(Butylamino)carbonyl]-2-[[(2,4-dichlorophenyl)sulfonyl] amino]phenoxy]-3-methoxy-benzeneacetic Acid

[1027847-67-1]

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Quality analytical standards and reference materials for food and environmental analysis, research

Founded in 1982, Toronto Research Chemicals is specialized in the development and production of reference materials used in research as well as food safety testing and environmental analysis. The range of more than 350,000 products includes reference standards for pesticides and metabolites, impurities, natural compounds and complex organic small molecules not otherwise commercially available.