Item no.
TRC-A425000-50MG
CAS Number
[134036-52-5]
Unit
50 mg
Shipment details
No Dangerous Good
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Description
Category: Aromatics, Pharmaceuticals, Intermediates and Fine Chemicals, Tyrosine Kinase Inhibitors, /// Appearance: Dark Yellow Solid /// Application Notes: A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo. /// References: Stock, J., et al.: J. Biol. Chem., 267, 19753
Structure formula
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