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Description

The transforming growth factor beta (TGFbeta) system, a superfamily of cytokines as well as signaling pathways, is highly conserved throughout the animal kingdom. TGFbeta functions in immune cell development, angiogenesis, wound healing and embryonic development, bone development and plays a critical role in immune response, heart disease, and cancer. In its normal state TGFbeta is one of the few classes of proteins able to inhibit cell growth by halting mitosis at the G1 state, inducing cell differentiation or apoptosis. However, during oncogenesis mutations in the TGFbeta signaling pathway result in tumor cell resistance to the effects of normally functioning TGFbeta, causing proliferation without regulation. Initial research suggests that VE-cadherin may enhance the mutated TGFbeta signaling pathway. The MILLIPLEX(R) TGFbeta1 Single Plex Magnetic Bead Kit is a single plex kit to be used for the quantification of TGFbeta in serum, plasma, tissue/cell lysate and culture supernatant samples. The Luminex(R) xMAP(R) platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.Panel Type: Cytokines/Chemokines