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Description

Alzheimer&rsquo,s disease (AD) is a progressive neurological disorder characterized by the presence of amyloid-beta (A&beta,) plagues and neurofibrillary tangles. The accumulation of A&beta, plaques is an early event in the pathogenesis of AD. In AD research, there has been a growing need for in vivo A&beta, imaging by two-photon microscopy, which enables deep-brain-fluorescence imaging. BioTracker PyrPeg Amyloid-b Live Cell Dye is a two-photon fluorescent probe that specifically detects insoluble A&beta,, rather than tau and alpha-synuclein aggregates (1). This probe may serve as a useful blood-brain-barrier penetrating tool for optical and functional monitoring of insoluble forms of A&beta, aggregates in the AD model brain (1).Reference:1. Choi, Ji-Woo, et al. ",PyrPeg, a Blood&ndash,Brain-Barrier-Penetrating Two-Photon Imaging Probe, Selectively Detects Neuritic Plaques, Not Tau Aggregates.", ACS Chemical Neuroscience 11.12 (2020): 1801-1810.