Back to your search result

Description

Llama, camels, and alpacas are camelids that produce normal IgG1 like antibodies and also functional IgG isotypes that do not incorporate light chains and possess only heavy chains. These heavy-chain antibodies may constitute about 50% of the IgG in llama serum and as much as 75% of the IgG in camel serum. By virtue of their smaller size they exhibit better bio-distribution, tissue penetration, and monomeric behavior. IgG3 consists of dimers of short heavy chains, which are characterized by a normal Fc region without a CH1 domain. Although it lacks the CH1 region, it still retains an antigen binding domain called the VHH region. Clone 8E1 is shown to specifically bind to IgG3 and not to any of the IgG2 heavy chains. (Ref.: Daley, LP., et al. (2005). Clin. Diag. Lab. Immunol. 12(4), 380-386).