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Description

Mucin 5, subtype B, tracheobronchial (UniProt: E9Q5I3, also known as MUC5B ) is encoded by the Muc5b gene (Gene ID: 74180) in murine species. Mucins are high molecular weight glycoproteins that consist of a mucin core protein and O-linked carbohydrates. Mucins are present on the surface of, and are secreted by, many glandular epithelial cells. They provide a barrier between the luminal membranes of cells in the epithelium and their environment. Mucins consist of a nonglobular protein backbone (apomucin) and many O-linked glycans. The two principal polymeric mucins are reported in the airways. They are Mucin 5ac that is produced at low levels under healthy conditions, but increases during allergic inflammation or parasitic infection, and Mucin 5B that is produced at substantial levels under healthy conditions and modestly increases under conditions of allergic inflammation Mucin 5B is shown to be abnormally expressed in gastric carcinoma. (Ref.: Ren, B et al. (2015). (Biosci Rep. 35(3): e00220).