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Description

Kaposi's sarcoma-associated herpesvirus glycoprotein K8.1 (UniProt: O36551, also known as Glycoprotein K8.1, Glycoprotein K8.1A, Glycoprotein gp35/37, K8.1, K8.1 protein) is encoded by the K8.1 (also known as HHV8GK18_gp55) gene (Gene ID: 4961469) in Kaposi's sarcoma-associated herpesvirus (KSHV). Kaposi sarcoma virus is an oncogenic human g-herpesvirus that has been identified in AIDS patients in association with Kaposi's sarcoma. It can persist latently in host cells while expressing only a limited set of viral genes and maintaining its genome as extrachromosomal plasmids. This virus encodes two immunogenic class I glycoproteins, K8.1A and K8.1B. These glycoproteins have several serine and threonine residues that serves as potential sites for O-glycosylation. The 228-amino-acid-long K8.1A open reading frame (ORF) contains four N-glycosylation sites and the 167-amino-acid-long K8.1B ORF contains three N-glycosylation sites. Glycoprotein K8.1A is reported to mediate KSHV binding to target cells via interaction with heparan sulfate. This protein is involved in binding to target cells but is not required for viral entry into cells. Clone 4A4 detects both K8.1A and K8.1B glycoprotein and is shown to react with infected cell membranes and virion envelope. This antibody is shown to partially inhibit KSHV infection in HEK293 cells. (Ref.: Faure, A., et al. (2019). Proc. Natl. Acad. Sci. USA. 116(33), 16519-16528, Zhu, L., et al. (1999). Virology 262(1), 237-249).