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Description

Trinucleotide repeat-containing gene 6A, 6B, and 6C proteins (UniProt: Q8NDV7, Q9UPQ9, Q9HCJ0) are encoded by the TNRC6A, TNRC6B, and TNRC6C genes (Gene ID: 27327, 23112, and 57690), respectively in human. TNRC6 proteins are ubiquitously distributed and play a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). TNRC6 proteins are required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. They also serve as a scaffolding proteins and associate with argonaute proteins bound to partially complementary mRNAs. They can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. TNRC6 proteins are predominantly found in the cytoplasm under steady state conditions, however, they are also found in the nucleus and their nuclear import is mediated via the importin pathways. TNRC6A is shown to posses both nuclear localization (NLS) as well a nuclear export signal (NES). In case of mutated NES, TNRC6A is shown to be retained in the nucleus. TNRC6 proteins contain RRM domains (aa 1781-1853, 1648-1720, and 1563-1632 for TNRC6A, 6B, and 6C, respectively). Clone 7A9 recognizes all three TNRC6 proteins. (Ref.: Schraivogel, D., et al. (2015). Nucleic Acids Res. 43(15), 7447-7461).