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Description

Somatotropin (UniProt P01241, also known as GH, GH-N, Growth hormone 1, hGH-N, Pituitary growth hormone) is encoded by the GH1 (also known as GH, GHN, IGHD1B) gene (Gene ID 8856) in human. Somatotropin is a peptide hormone that plays an important role in growth control by inducing IGF-1 secretion in liver and other tissues. It stimulates myoblast differentiation and proliferation, as well as amino acids uptake and protein synthesis in muscle and other tissues. Acromegaly is a rare endocrine syndrome caused by a GH-secreting pituitary adenoma. Acromegaly may also be rarely associated with a hypothalamic or an ectopic GH-releasing hormone-producing tumor.