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Description

Cardiomyocytes are the cardiac muscle cells that make up the heart and are responsible for generating contractile forces within the heart. Laminin-221 is known to bind to the integrin alpha7X2beta1 which is located on the cell surface of pluripotent stem cells and is known to induce cardiac and skeletal muscle differentaition. Professor Kiyotoshi Sekiguchi's group (Matrixome, Inc.) have produced a recombinant E8 fragment of laminin-221 at large-scale while retaining the full integrin binding activity. ECMatrix-221 E8 Laminin Substrates are recombinant Laminin-221-E8 fragments which bind to integrin alpha7X2beta1 and increases the differentiation of pluripotent stem cells (ES/iPSCs) into functional cardiomyocytes.