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Description

Secreted frizzled-related protein 1 (UniProt Q8N474, also known as FRP-1, SARP-2, Secreted apoptosis-related protein 2, sFRP-1) is encoded by the SFRP1 (also known as FRP, FRP1, SARP2) gene (Gene ID 6422) in human. Canonical Wnt signaling is constitutively suppressed in the absence of Wnt, and its activation in the presence of Wnt can be blocked by secreted inhibitors, including the dickkopf-related proteins (DKK) and the secreted frizzled-related proteins (sFRP1-5). sFRPs share homology with the FZD receptor and compete againt FZD for Wnt binding in the extracellular space, sFRPs may also exert their effects by interacting with each other and FZD receptors. sFRP-1 is present during both cardiac development and adult life and is abundantly expressed in the mouse and human heart. Study conducted with Sfrp1-knockout mice indicates a role of sFRP-1 in age-related cardiac deterioration and fibrosis. Human sFRP-1 is produced with a signal peptide sequence (a.a. 1-31), the removal of which yields the mature protein (a.a. 32-314) with an N-terminal FZ (a.a. 53-169) domain, followed by a netrin (NTR) domain (a.a. 186-306).