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Description

Pro-thyrotropin-releasing hormone (UniProt: P01150, also known as Pro-TRH, Prothyroliberin, TRH, TSH-releasing factor, Thyrotropin-releasing factor, TRF) is encoded by the Trh gene (Gene ID: 25569) in rat. TRH is a secreted hypothalamic protein that travels across the median eminence to the pituitary via the hypophyseal portal system. It functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. Pro-TRH (TRH-potentiating peptide: Ps4) is co-synthesized with TRH serves as a marker for TRH-containing neurons. Like TRH itself, pro-TRH is biologically active.