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Description

LIM domain-binding protein 1 (UniProt P70662, CLIM-2, LDB-1) encoded by the murine Ldb2 gene (Clim2, Nli, Gene ID 16825) and LIM domain-binding protein 2 (UniProt O55203, CLIM-1, LDB-2, CLP-36) encoded by the murine Ldb2 gene (Clim1, Gene ID 16826) are LIM domain-interacting cofactors whose interaction with LIM homeodomain (LIM-HD) transcription factors are crucial for the development of specific types of interneurons and motor neurons during neural tube development. The ubiquitin ligase RLIM targets CLIM for proteasomal degradation, thereby inhibiting developmental LIM-HD activity.