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Description

This support consists of MBHA resin functionalized with Riniker&prime,s hyperacid-labile 4-hydroxymethyl-3-methoxyphenoxybutyric acid linker [1].This hyperacid-sensitive resin is a useful tool for the Fmoc SPPS of protected peptide acid fragments.Attachment of carboxylic acids is normally achieved by DMAP catalyzed esterification with the appropriate symmetrical anhydride, or by using 2,6-dichlorobenzoyl chloride/pyridine [2] or MSNT/Melm activation [3, 4, 5].Detachment of these functionalities can be effected by treatment with 1-5% TFA in DCM.The product number for this product was previously 01-64-0036.To obtain a certificate of analysis (CoA) of a lot that begins with the letter &ldquo,A&rdquo,, please select the option in the right hand menu &ldquo,Request a COA for Lot#s starting with A&rdquo,.