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Description

A cell-permeable, potent, and selective activator of Wnt signaling that does not inhibit the activity of GSK-3beta (IC50 >60 µ,M). Shown to mimic the effect of Wnt and induce beta-catenin and TCF (T-cell fate)-dependent transcriptional activity (EC50 = 700 nM in HEK-293T cells). Reported to cause substantial head defects during Xenopus embryonic development., A cell-permeable pyrimidine compound that acts as a potent and selective activator of Wnt signaling without inhibiting the activity of GSK-3beta (IC50 >60 µ,M). Shown to mimic the effect of Wnt and induce beta-catenin and TCF (T-cell fate)-dependent transcriptional activity (EC50 = 700 nM in HEK-293T cells), and cause substantial head defects during Xenopus embryonic development. Also available as a 10 mM solution in DMSO (Cat. No. 681664).