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Description

A cell-permeable and potent inducer of VEGF and VEGF-mediated blood vessel formation. GS4012-induced upregulation of VEGF correlates with its ability to suppress the gridlock/coarctation phenotype (7.5 µ,g/ml) in Zebrafish and to stimulate tubule network formation (5 µ,g/ml) in HUVECs. An essential molecule required during angioblasts cell fate determination., A cell-permeable pyridinyl-thioether compound that acts as a potent inducer of VEGF and VEGF-mediated vessel formation. GS4012-induced upregulation of VEGF correlates well with its ability to suppress the gridlock/coarctation phenotype (7.5 µ,g/ml) in Zebrafish and to stimulate tubule network formation (5 µ,g/ml) in HUVECs.