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Description

A synthetic, cell-permeable peptide that corresponds to mouse toll-interleukin 1 receptor (TIR) domain-containing adapter protein 138-151 (TIRAP, also called Mal (MyD88-adapter-like), fused to the Drosophila antennapedia sequence. Shown to specifically inhibit LPS-induced, but not CpG-induced, NF-kappaB activation, PKR phosphorylation, and JNK phosphorylation in RAW.kappaB cells at ~40 µ,M. Also reported to block IkappaBalpha degradation., A cell-permeable synthetic peptide containing mouse TIRAP138-151 fused to the Drosophila Antennapedia sequence. Specifically inhibits LPS-, but not CpG-induced NF-kappaB activation, PKR phosphorylation, and JNK phosphorylation in RAW.kappaB cells at ~40 µ,M. Also reported to block IkappaBalpha degradation.