Item no.
SAF-613551-5MG
CAS Number
[552309-42-9]
Unit
1 x 5 mg
Molecular formula
C19H20N4O3S2
Molecular weight
416,52
Shipment details
No Dangerous Good /not restricted
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Description
An aminophenylthiazole that acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µ,M). Fully blocks CaCC current in salivary gland cells at 10 µ,M, but has very little effect in airway and intestinal cells, which is consistent with the observation of RNAi knock-down. Completely blocks chloride currents produced by TMEM16A Activator, Eact (Cat. No. 631547) at 10 µ,M. In addition, shown to block calcium-activated chloride channels in vascular smooth muscle cells, and relaxes murine and human blood vessels.
Hazards
Structure formula
Contents
Miscellaneous
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