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Description

A convenient four-vial pack containing ~50 mg each of all-rac-alpha, all-rac-beta, RRR-gamma, and RRR-delta-tocopherols for use as reference standards for the quantitative and qualitative determination of tocopherols in biological samples. The term vitamin E covers several related tocopherols (all-rac-alpha-, all-rac-beta-, RRR-gamma-, RRR-delta-tocopherols) and tocotrienols that have been isolated from natural sources. Of these compounds, alpha-tocopherol is reported to have the highest biological activity. Most studies in human subjects rely on all-rac-alpha-tocopherol concentrations in plasma or serum to assess vitamin E status. The biological activity of vitamin E has generally been associated with its well-defined antioxidant property, specifically against lipid peroxidation in biological membranes. With the emergence of a better understanding of the antioxidant effect of vitamin E, researchers have shown it to possess several potentially anti-tumor and cardioprotective properties, including antagonizing the oxidation of low-density lipoproteins, inhibiting platelet aggregation and adhesion, preventing smooth muscle proliferation, and preserving normal coronary dilation. More recently, the observation that all-rac-alphatocopherol has a signaling function in vascular smooth muscle cells has raised interest in the roles of vitamin E beyond its antioxidative function. The RRR-gamma-tocopherol has been shown to act as a nucleophile that can trap electrophilic mutagens in lipophilic compartments., Contains one 50 mg vial each of all-rac-alpha-tocopherol, all-rac-beta-tocopherol, RRR-gamma-tocopherol, and RRR-delta-tocopherol.