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Description

A cell-permeable pentafluorosulfonamide compound that covalently binds to beta-tubulin and induces microtubule depolymerization and cell-cycle arrest by irreversibly modifying beta-tubulin. T113242-induced activation of gene transcription has been shown to be mediated by the Erk signaling pathway and the transcription factor MIZ-1 (myc-interacting zinc finger protein)., A cell-permeable pentafluorosulfonamide compound that induces microtubule depolymerization and cell-cycle arrest by irreversibly modifying beta-tubulin. T113242-induced activation of gene transcriptions has been shown to be mediated by Erk signalling pathway and the transcription factor MIZ-1 (myc-interacting zinc finger protein).