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Description

An active metabolite of the non-steroidal anti-inflammatory drug Sulindac (Cat. No. 574100). Inhibits Ras signaling. Strongly inhibits Ras-induced malignant transformation and Ras/Raf-dependent transactivation. Also decreases the Ras-induced activation of c-Raf-1 kinase. Inhibits cell growth and induces apoptosis in a time-and dose-dependent manner. Selectively inhibits prostaglandin H synthase-1 (PGHS-1, COX-1, ID50 = 0.5 µ,M) relative to prostaglandin H synthase-2 (PGHS-2, COX-2, ID50 = 14 µ,M). Reduces Abeta42 production independently of COX inhibition., A cell-permeable, active metabolite of Sulindac (Cat. No. 574100). Strongly inhibits Ras-induced malignant transformation and Ras/Raf-dependent transactivation. Also decreases the Ras-induced activation of c-Raf-1 kinase. Inhibits growth and induces apoptosis in prostate cancer cell lines. Selectively inhibits COX-1 (ID50 = 500 nM) compared to prostaglandin H synthase-2 (PGHS-2, COX-2, ID50 = 14 µ,M). Preferentially inhibits the secretion of Abeta42 in CHO cells stably transfected with both APP75, and the PS1 mutant M146L.