Item no.
SAF-573099-25MG
CAS Number
[19983-44-9]
Unit
1 x 25 mg
Molecular formula
C8H5NO4S
Molecular weight
211,19
Shipment details
No Dangerous Good /not restricted
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Description
A cell-permeable vinyl-sulfone compound that acts as an inhibitor of STAT3 cellular function by targeting the STAT3-SH2 domain and preventing its association with upstream kinases. The effect of Stattic towards STAT family members is temperature-dependent and appears to be highly STAT3-selective at 37C. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells).
Hazards
Structure formula
Contents
Miscellaneous
Certificate of Analysis (specimen)
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Product data sheet
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