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JAK2 Inhibitor III, SD-1029 The JAK2 Inhibitor III, SD-1029, also referenced under CAS 118372-34-2, controls the biological activity of JAK2.

Item no.

SAF-573098-10MG

Unit

1 x 10 mg

Shipment details

No Dangerous Good

Price on request

Description

A cell-permeable xanthenedione compound that acts as a JAK2-selective inhibitor. It exhibits much less effect on the cellular phosphorylation levels of Jak1 and Src and shows no significant inhibition towards a panel of 49 other protein kinases in cell-free kinase assays at a concentration of 10 µ,M. Effectively inhibits cell proliferation in JAK-activated BA/F3 cell lines as well as phosphorylation and nuclear translocation of cellular Stat3.

Structure formula

Miscellaneous

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Product data sheet

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