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Description

A potent inhibitor of Src-family protein tyrosine kinases. Inhibits Src (IC50 = 280 nM) as well as closely related kinases Fyn (IC50 = 170 nM), Yes (IC50 = 20 nM) and Lyn (IC50 = 130 nM). The inhibition is competitive with respect to ATP. Has only a trivial effect on Lck (IC50 = 6.88 µ,M). Does not affect the activity of PDGF-beta receptor kinase (IC50 >10 µ,M) and IGF-1 receptor kinase (IC50 gt,20 µ,M).