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Description

An arylcarboxamide that acts as a potent and selective sphingosine-1-phosphate receptor 4 (S1P4) antagonist (IC50 = 25 nM), among a panel of five S1P receptors. It is shown to inhibit other S1P isoforms only at much higher concentrations (IC50 = 6.4 µ,M, 3.9 µ,M, 5.5 µ,M, and 25 µ,M for S1P1, S1P2, S1P5, and S1P3 (95% inhibition), respectively).

Structure formula

SAF-567737-5MG

Miscellaneous

Certificate of Analysis (specimen)

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Product data sheet

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