Item no.
SAF-567732-10MG
Unit
1 x 10 mg
Molecular formula
C21H22N4O4
Molecular weight
394,42
Shipment details
No Dangerous Good
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Description
A cell-permeable pyrazolocarbohydrazide compound that acts as a potent, reversible, sphingosine competitive and ATP-non-competitive inhibitor of sphingosine kinase 1 (SphK1) activity with excellent selectivity over SphK2 (Ki = 1.33 and >>25 µ,M, respectively). Shown to suppress sphingosine-1-phosphate (S1P) production in A549 cells and efficiently induce apoptosis in several tumor cells (IC50 in the range of 0.1-1.8 µ,M).
Structure formula
Miscellaneous
Certificate of Analysis (specimen)
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Product data sheet
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