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SHP1/2 PTPase Inhibitor, NSC-87877 - CAS 56932-43-5 - Calbiochem The SHP1/2 PTPase Inhibitor, NSC-87877, also referenced under CAS 56932-43-5, controls the biological activity of SHP1/2 PTPase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Item no.

SAF-565851-50MG

CAS Number

[56932-43-5]

Unit

1 x 50 mg

Molecular formula

C19H11N3Na2O7S2

Molecular weight

503,42

Shipment details

No Dangerous Good

Price on request

Description

A cell-permeable 7-aza-8-hydroxyquinoline compound that acts as a potent, catalytic site-targeting inhibitor of SHP-1 and SHP-2 protein tyrosine phosphatases (IC50 = 355 nM and 318 nM, respectively). It inhibits PTP1B and HePTP with less potency (IC50 = 1.69 µ,M and 7.75 µ,M, respectively) and exhibits >200-fold selectivity over DEP1, CD45, and LAR. Shown to inhibit both basal and stimulated SHP-2 activity in HEK293 cells.

Structure formula

Miscellaneous

Certificate of Analysis (specimen)

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Product data sheet

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