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InSolution beta-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem The InSolution beta-Secretase Inhibitor, also referenced under CAS 797035-11-1, controls the biological activity of beta-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

Item no.

SAF-565794-500UG

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Description

A cell-permeable isophthalamide compound containing hydroxyethylamine motif that binds to BACE-1 active site and potently blocks its proteolytic activity (IC50 = 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells). Displays greater selectivity over other aspartyl proteases (IC50 = 0.23 µ,M, 7.6 µ,M and >50 µ,M for BACE-2, cathepsin D, and renin, respectively). The solid form of this compound (Cat. No. 565788) is also available.

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