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Description

An internally quenched fluorogenic peptide substrate that contains the &alpha,-secretase cleavage site of &beta,-amyloid precursor protein (APP). Shown to be an effective substrate for yapsin-2, a glycosyl-phosphatidylinositol-linked aspartyl protease found in yeast (Vmax/Km = 0.031 min-1). The cleavage has been shown to occur at the Lys-Leu bond. Excitation max: ~340 nm, emission max: ~490 nm., An internally quenched fluorogenic peptide substrate containing the &alpha,-secretase cleavage site of &beta,-Amyloid Precursor Protein (APP). Shown to be a substrate for yapsin 2, a glycosyl-phosphatidylinositol-linked yeast aspartyl protease (Vmax/Km = 0.031 min-1). The cleavage is shown to occur at the Lys-Leu bond.