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Description

An internally quenched fluorogenic peptide substrate containing the C-terminal beta-APP (amyloid beta-peptide precursor protein) amino acid sequence that is cleaved by gamma-secretase. Shown to be sensitive and useful for assaying gamma-secretase activity. The proteolysis at the Abeta40-, Abeta42-, and Abeta43-generating cleavage sites results in enhanced fluorescence. Excitation max.: ~355 nm, emission max.: ~440 nm., An internally quenched fluorogenic peptide substrate containing the C-terminal beta-APP (amyloid beta-peptide precursor protein) amino acid sequence that is cleaved by gamma-secretase. Shown to be sensitive and useful for assaying gamma-secretase activity. The proteolysis at the Abeta40-, Abeta42-, and Abeta43-generating cleavage sites results in enhanced fluorescence.