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Description

A selective cell-permeable protein kinase C inhibitor. Displays about a 10-fold greater selectivity for PKCalpha (IC50 = 9 nM) and a 4-fold greater selectivity for PKCbetaI (IC50 = 28 nM) over PKCepsilon (IC50 = 108 nM). Also prevents T-cell driven chronic inflammatory responses in vivo., A selective cell-permeable protein kinase C inhibitor. Displays about 10-fold greater selectivity for PKCalpha (IC50 = 9 nM) and 4-fold greater selectivity for PKCbetaI (IC50 = 28 nM) over PKCepsilon (IC50 = 108 nM). Also prevents T cell-driven chronic inflammatory responses in vivo.Please note that the molecular weight for this compound is batch-specific due to variable water content.