Back to your search result

Rho/SRF Pathway Inhibitor, CCG-1423 - CAS 285986-88-1 - Calbiochem The Rho/SRF Pathway Inhibitor, CCG-1423, also referenced under CAS 285986-88-1, controls the biological activity of Rho/SRF. This small molecule/inhibitor is primarily used for Cell Structure applications.

Item no.

SAF-555558-25MG

Unit

1 x 25 mg

Shipment details

No Dangerous Good

Price on request

Description

A cell-permeable benzamide compound that acts as an effective inhibitor against RhoA- and RhoC-mediated cellular activities by targeting signaling events downstream of Galpha12/13 and RhoA/C, affecting MKL recruitment and/or postrecruitment function of MKL1, but not SRF-SRE interaction or ROCK kinase activity. CCG-1423 is shown to inhibit RhoC-dependent cell growth in A375M2 and SK-Mel-147 (IC50 <=300 nM) and block RhoC/ Galpha12-mediated PC-13 invasion in Matrigel assays (by ~90% at 3 µ,M). Shown to inhibit MICAL-2 with a Ki of 1.5 µ,M.

Structure formula

Miscellaneous

Certificate of Analysis (specimen)

Reference Material CoA specimen: for the current lot, please contact your customer service representative at info@labmix24.com

Product data sheet

View all available product details e.g. description, analytes/parameters, CAS Number, concentrations/values, sales unit/product format, method, source, transport information