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Description

A phenolic product found in both grape skins and wines. Has antifungal, antitumor, and antioxidative properties. A specific inhibitor of cyclooxygenase-1 (COX-1, ED50 = 15 µ,M). Also inhibits the hydroxyperoxidase activity of COX-1 (ED50 = 3.7 µ,M). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Inhibits phorbol ester-induced free radical formation in HL-60 cells (ED50 = 27 µ,M) and acts as an anti-mutagenic agent (ED50 = 15 µ,M) in TM677 cells treated with DMBA. Also a selective inhibitor of P450 1A1. Reported to activate sirtuins and promote the survival of eukaryotic cells., A phenolic product found in both grape skin and wines. Has anti-fungal, anti-tumor and antioxidative properties. A specific inhibitor of cyclooxygenase-1 (COX-1, ED50 = 15 µ,M). Also inhibits the hydroxyperoxidase activity of COX-1 (ED50 = 3.7 µ,M). Inhibits phorbol ester-induced free radical formation in HL-60 cells (ED50 = 27 µ,M) and acts as an anti-mutagenic agent (ED50 = 15 µ,M) in TM677 cells treated with DMBA. Also selectively inhibits P450 1A1. Reported to activate sirtuins and promote the survival of eukaryotic cells.