Item no.
SAF-553509-10MG
CAS Number
[171927-40-5]
Unit
1 x 10 mg
Molecular formula
C16H20N4O3
Molecular weight
316,36
Shipment details
No Dangerous Good
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Description
A cell-permeable pyrazoloquinoline compound that acts as an effective blocker of Ras-induced malignant transformation and inhibits Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex and membrane ruffling. The effect of SCH 51344 is limited to Ras/Rac pathway(s) other than those involving ERK and JNK. Shown to directly target human mutT homolog MTH1/NUDT1 with a Kd of 49 nM and inhibit its catalytic activity (IC50 for pyrophosphate release during nucleotide triphosphate hydrolysis = 215, 410 and 675 nM against dGTP, 8-oxo-dGTP and 2-OH-dATP substrates, respectively).
Structure formula
Contents
Miscellaneous
Certificate of Analysis (specimen)
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