Item no.
SAF-553031-10MG
Unit
1 x 10 mg
Molecular formula
C57H101N13O17S
Molecular weight
1272,55
Shipment details
No Dangerous Good
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Description
An S100P-derived peptide based competitive antagonist for receptor for advanced glycation end product (RAGE). Shown to disrupt the interaction between RAGE and its ligands, such as S100P, S100A4 and HMGB-1 in binding assays and in multiple cancer cell lines (~2 µ,M). Also, blocks RAGE-dependent NF-kB activation in MPanc96, MOH and HPAF II tumor cell lines. Systemic administration of RAP also diminishes NF-kB signaling in vivo and significantly reduces glioma tumor growth in murine models.
Structure formula
Miscellaneous
Certificate of Analysis (specimen)
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Product data sheet
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