Item no.
SAF-553008-1MG
CAS Number
[220904-83-6]
Unit
1 x 1 mg
Molecular formula
C15H8Br2INO2
Molecular weight
520,94
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Description
A potent, cell-permeable, reversible, and ATP-competitive cRAF1 kinase inhibitor (IC50 = 9 nM). Shows >=100-fold selectivity for Raf kinase versus Cdk1, Cdk2, c-Src, ERK2, MEK, p38, Tie2, VEGFR2, and c-Fms. Predicted broad spectrum antitumor agents. A 10 mM (500 µ,g/96 µ,l) solution of Raf1 Inhibitor I (Cat. No. 553003) in DMSO is also available., A potent, cell-permeable, reversible, and ATP-competitive cRaf1 kinase inhibitor (IC50 = 9 nM). Shows >=100-fold selectivity for Raf kinase versus Cdk1, Cdk2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fms. cRaf1 inhibitors are predicted to be broad spectrum antitumor agents.
Structure formula
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