Item no.
SAF-551590-5MG
CAS Number
[90-18-6]
Unit
1 x 5 mg
Molecular formula
C15H10O8
Molecular weight
318,25
Shipment details
No Dangerous Good
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Description
A cell-permeable flavanol compound that acts a potent, ATP-competitive, and reversible inhibitor of PIM1 kinase (IC50 = 340 nM). Exhibits >=7-fold selectivity over 8 other kinases tested, including PIM2 (IC50 = 3.45 µ,M), and little activity toward c-Abl even at concentrations as high as 200 µ,M. Inhibits cellular BAD phosphorylation (IC50 = 5.5 µ,M) and induces growth arrest (ED50 = 3.8 µ,M) in PIM1-expressing RWPE2 cells.
Structure formula
Contents
Miscellaneous
Certificate of Analysis (specimen)
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Product data sheet
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