Item no.
SAF-550602-10MG
Unit
1 x 10 mg
Molecular formula
C18H18F2N2O6S2
Molecular weight
460,47
Shipment details
No Dangerous Good
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Description
A cell-permeable diarylsulfonamide (DASA) compound that acts as a potent and selective activator of tumor-specific M2 isozyme of pyruvate kinase (PKM2, AC50 = 65 nM). Pretreatment of A549 (adenocarcinomic human alveolar basal epithelial cells) with DASA-10 (~10 µ,M) prevents hydrogen peroxide, diamide, and hypoxia-induced inactivation of PKM2. DASA treatment is shown to cause a diminution in cellular glutathione levels, and higher oxidative stress-induced cell death.
Structure formula
Miscellaneous
Certificate of Analysis (specimen)
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Product data sheet
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