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PTP Inhibitor V, PHPS1 - CAS 314291-83-3 - Calbiochem The PTP Inhibitor V, PHPS1, also referenced under CAS 314291-83-3, controls the biological activity of PTP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Item no.

SAF-540213-10MG

CAS Number

[314291-83-3]

Unit

1 x 10 mg

Molecular formula

C21H15N5O6S

Molecular weight

465,44

Shipment details

No Dangerous Good

Price on request

Description

A cell-permeable phosphotyrosine mimetic that acts as a reversible, active-site targeting, substrate-competitive inhibitor of Shp-2 (IC50 and Ki = 2.1 and 0.73 µ,M, respectively). PHPS1 inhibits ECPTP, PTP1B, Shp1, mycobacterium MptpA only at higher concentrations (IC50 = 5.4, 19, 30, and 39 µ,M, respectively) and exhibits little activity against PTPH1, STEP, PTPN7, PTPRK, GLEPP1, or LAR2 even at concentrations as high as 50 µ,M. Shown to inhibit Shp-2-dependent cellular signaling and tumor cell colonies formation.

Structure formula

Miscellaneous

Certificate of Analysis (specimen)

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Product data sheet

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