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PTP Inhibitor IV - CAS 329317-98-8 - Calbiochem The PTP Inhibitor IV, also referenced under CAS 329317-98-8, controls the biological activity of PTP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Item no.

SAF-540211-10MG

CAS Number

[329317-98-8]

Unit

1 x 10 mg

Molecular formula

C26H26F6N2O4S2

Molecular weight

608,62

Price on request

Description

An uncharged, 1,4-di-substituted, phenyl-linked, bis-trifluoromethylsulfonamido (TFMS) phosphate mimetic that acts as a potent, reversible, substrate competitive, active-site-directed inhibitor of protein tyrosine phosphatases (PTP). Reported to inhibit SHP-2 (IC50 = 1.8 microM), PTP1B (IC50 = 2.5 microM), PTP-&epsilon, (IC50 = 8.4 microM), PTP-Meg-2 (IC50 = 13 microM), PTP-&sigmaf, (IC50 = 20 microM), PTP-&beta, (IC50 = 6.4 microM), and PTP-micro (IC50 = 6.7 microM)., An uncharged, 1,4-di-substituted, phenyl-linked bis-trifluoromethylsulfonamido (TFMS) phosphate mimetic that acts as a potent, reversible, competitive, and active-site directed inhibitor of protein tyrosine phosphatases (PTP, IC50 = 1.8, 2.5, 8.4, 13, 20, 6.4, and 6.7 microM for SHP-2, PTP1B, PTP-&epsilon,, PTP-Meg-2, PTP-&sigmaf,, PTP-&beta,, and PTP-micro, respectively).

Structure formula

N,N'-[1,4-Phenylenebis[(1-methylethylidene)-4,1-phenylene]]bis[1,1,1]-trifluoro-methanesulfonamide

Analyte	CAS Number	Concentration	Unit	Additional information	Method
N,N'-[1,4-Phenylenebis[(1-methylethylidene)-4,1-phenylene]]bis[1,1,1]-trifluoro-methanesulfonamide	[329317-98-8]

Miscellaneous

Certificate of Analysis (specimen)

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Product data sheet

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