Item no.
SAF-539162-1MG
Unit
1 x 1 mg
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Description
A potent, cell-permeable, and reversible proteasome inhibitor. Inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (MPC, Ki = 460 nM). Does not inhibit the peptidyl-glutamyl peptide hydrolyzing activity of MPC even at concentrations of 200 µ,M. Also blocks the decay of IkappaB-alpha and IkappaB-beta proteins in exponentially growing WEHI 231 cells.
Structure formula
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