Back to your search result

Description

A cell-permeable indenopyrazole based compound that potently suppresses hypoxia-induced HIF-1alpha transcription (IC50 = 14 nM in HRE-Luc HeLa cells) and VEGF-expression. Shown to effectively induce growth arrest in several cancer cells (IC50 = 2.1, 3.7 & 1.8 µ,M for HCT116, HepG2 & HeLa cells), although with reduced efficiency in PC3 (IC50 = 25.4 µ,M). Does neither affect HIF-1alpha protein accumulation nor HIF-1alpha/HIF-1beta heterodimer complex formation. Suggested to act via impairing HIF-1alpha/HIF-1beta heterodimer-induced transcriptional pathway.Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water., A cell-permeable indenopyrazole based compound that potently suppresses hypoxia-induced HIF-1alpha transcription (IC50 = 14 nM in HRE-Luc HeLa cells) and VEGF-expression. Shown to effectively induce growth arrest in several cancer cells (IC50 = 2.1, 3.7 & 1.8 µ,M for HCT116, HepG2 & HeLa cells), although with reduced efficiency in PC3 (IC50 = 25.4 µ,M). Does neither affect HIF-1alpha protein accumulation nor HIF-1alpha/HIF-1beta heterodimer complex formation. Suggested to act via impairing HIF-1alpha/HIF-1beta heterodimer-induced transcriptional pathway.