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Description

A brain-penetrating 11-mer peptide derived from the active region of human ciliary neurotrophic factor (CTNF, aa 146-156) that rescues autism sera-induced cell death and oxidative stress in mouse cultured cortical neurons in a dose-dependent manner (5 nM to 1 µ,M). Also shown to abrogate behavioral autistic phenotype in autism sera induced rat model. Exerts its neuroprotective effect by modulating CNTF/JAK/STAT pathway and LIF signaling and by enhancing the expression of brain derived neurotrophic factor (BDNF). Enhances hippocampus-dependent learning and memory, increased neurogenesis and neuronal plasticity in normal adult mice. Exhibits desirable plasma half-life (6 hours) and is devoid of any adverse effects normally associated with the full-length protein. Potentiates neurogenesis in the AbetaPP Tg mice by augmenting cell proliferation.Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water., A brain-penetrating 11-mer peptide derived from the active region of human ciliary neurotrophic factor (CTNF, aa 146-156) that rescues autism sera-induced cell death and oxidative stress in mouse cultured cortical neurons in a dose-dependent manner (5 nM to 1 µ,M). Also shown to abrogate behavioral autistic phenotype in autism sera induced rat model. Exerts its neuroprotective effect by modulating CNTF/JAK/STAT pathway and LIF signaling and by enhancing the expression of brain derived neurotrophic factor (BDNF). Enhances hippocampus-dependent learning and memory, increased neurogenesis and neuronal plasticity in normal adult mice. Exhibits desirable plasma half-life (6 hours) and is devoid of any adverse effects normally associated with the full-length protein. Potentiates neurogenesis in the AbetaPP Tg mice by augmenting cell proliferation.Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.