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TRPML3 Activator, ML123 - Calbiochem A highly selective agonist of TRPML3 channel (EC?? = 873 nM)

Item no.

SAF-5335740001

Unit

Molecular formula

C16H23ClN2O3S

Molecular weight

358,88

Price on request

Description

A non-cytotoxic morpholinyl-cyclohexylbenzenesulfonamide compound that acts as a selective agonist of TRPML3 channel (EC50 = 873 nM in hTRPML3-YPF transfected HEK293 cells). Displays significantly weaker agonistic activity for TRPML2 channel (54.5% at 10 microM) and is shown to be inactive against hTRPML1, hTRPM2, mTRPV2, hTRPC3, drTRPN1, and hTRPA1 (~10 microM). Also binds to sigma-1 receptor at much higher concentrations (IC50 = 31 microM).

Structure formula

4-Chloro-N-(2-morpholinocyclohexyl)benzenesulfonamide

Miscellaneous

Certificate of Analysis (specimen)

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Product data sheet

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