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Description

A cell-permeable phenylsulfonamide compound that reversibly binds to pocket I of the monomeric alpha-synuclein (alpha-syn) and reverses alpha-syn-induced impairment of phagocytosis in H4 neuroglioma cells over-expressing wild-type alpha-syn and microglia isolated from alpha-syn BAC transgenic animals over-expressing the E46K mutant form of human alpha-syn (~1-10 µ,M). Reduces alpha-syn-mediated impairment of vesicular dynamics and diminishes alpha-syn translocation to the synaptic region in rat primary neuronal cultures by 50% (at ~ 1 µ,M) and in cortical cultures in transgenic mice over-expressing human alpha-syn. Also shown to protect dopaminergic neurons against the toxic effects of over-expressed alpha-syn A53T and reduces neurite retraction in TH- and MAP2-positive neurons., A cell-permeable phenylsulfonamide compound that reversibly binds to pocket I of the monomeric alpha-synuclein (alpha-syn) and reverses alpha-syn-induced impairment of phagocytosis in H4 neuroglioma cells over-expressing wild-type alpha-syn and microglia isolated from alpha-syn BAC transgenic animals over-expressing the E46K mutant form of human alpha-syn (~1-10 µ,M). Reduces alpha-syn-mediated impairment of vesicular dynamics and diminishes alpha-syn translocation to the synaptic region in rat primary neuronal cultures by 50% (at ~ 1 µ,M) and in cortical cultures in transgenic mice over-expressing human alpha-syn. Also shown to protect dopaminergic neurons against the toxic effects of over-expressed alpha-syn A53T and reduces neurite retraction in TH- and MAP2-positive neurons.Please note that the molecular weight for this compound is batch-specific due to variable water content.