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Description

A cell-permeable, non-toxic, n-octyl ester form of 5-carboxy-8-hydroxyquinoline (IOX1, Cat. No. 420201) that acts as a superior inhibitor of Jumonji C domain histone lysine demethylase. Shown to be about 30 fold more potent than IOX1 (EC50 = 3.8 microM for KDM4A in HeLa cells vs. 100 microM for IOX1). Inhibits the H3K9 me3 demethylation activity of KDM4C (IC50 = 3.9 microM in ALPHA Screen assay). Exhibits greater stability to hydrolysis in the ALPHA Screen buffer., A cell-permeable, non-toxic, n-octyl ester form of 5-carboxy-8-hydroxyquinoline (IOX1, Cat. No. 420201) that acts as a superior inhibitor of Jumonji C domain histone lysine demethylase. Shown to be about 30 fold more potent than IOX1 (EC50 = 3.8 microM for KDM4A in HeLa cells vs. 100 microM for IOX1). Inhibits the H3K9 me3 demethylation activity of KDM4C (IC50 = 3.9 microM in ALPHA Screen assay). Exhibits greater stability to hydrolysis in the ALPHA Screen buffer.Please note that the molecular weight for this compound is batch-specific due to variable water content.