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PARP Inhibitor XIV - CAS 1104546-89-5 - Calbiochem The PARP Inhibitor XIV, also referenced under CAS 1104546-89-5, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

Item no.

SAF-528824-10MG

CAS Number

[1104546-89-5]

Unit

1 x 10 mg

Shipment details

No Dangerous Good /not restricted

Price on request

Description

A cell-permeable isoquinolinedione compound that potently inhibits PARP-1 activity (pIC50 = 7.35, IC50 = 45 nM) in a NAD+-competitive and reversible manner, while affecting PPAR-2 activity with a 100-fold lower potency. Selectively inhibits PARP-1-mediated cellular PAR formation and is of little effect against PAR formation in fibroblasts derived from parp-1(-/-) mice. Its in vivo application is limited by a poor aqueous solubility (~9 µ,M).

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Structure formula

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